The Cattedrale di Santa Maria Assunta serves as the primary religious structure in Minervino Murge. Originally constructed by the Normans, the cathedral has undergone several reconstructions, resulting in a captivating fusion of Gothic and Baroque architectural elements. It is particularly significant as the final resting place of two consorts of Frederick II, Holy Roman Emperor. The church is appreciated for its simple yet elegant design, and the pastor is known for assisting those engaged in genealogical research. Guests often remark on the beautiful facade and the stunning interior, including the stained glass above the altar and the colorful statues of saints.